Conserved Determinants for CD4+ T Cells within the Light Chain of the H3 Hemagglutinin Molecule of Influenza Virus
Identifieur interne : 001E42 ( Main/Exploration ); précédent : 001E41; suivant : 001E43Conserved Determinants for CD4+ T Cells within the Light Chain of the H3 Hemagglutinin Molecule of Influenza Virus
Auteurs : David C. Jackson [Australie] ; Heidi E. Drummer [Australie] ; Lorena E. Brown [Australie]Source :
- Virology [ 0042-6822 ] ; 1994.
Abstract
Abstract: Helper T-cell clones were isolated from BALB/c mice that had been inoculated with purified light chain (HA2) from H3 subtype influenza virus hemagglutinin (HA). The clones were divided into two distinct groups based on their ability to proliferate in response to bromelain-derived HA (BHA) and the light chain derived from it (BHA2), both of which lack the C-terminal 46 amino acid residues of the HA2 chain. The first group contained two I-Ad restricted clones that proliferated in response to BHA and BHA2 and were found to recognize the determinant 96 AELLVALEN104. The remaining seven clones were I-Ed restricted, required intact HA2 for proliferation, and responded to synthetic peptides containing the sequence 170 RFQIKGVEL178 which spans the bromelain cleavage site. Although all T-cell clones proliferated in response to a wide range of different H3 virus strains, they showed no cross-reactivity with viruses of the H1 or H2 subtype. The T-cell clones from each group were able to provide help to virus-primed B cells allowing them to produce anti-HA antibody in vitro.
Url:
DOI: 10.1006/viro.1994.1073
Affiliations:
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Jackson</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, University of Melbourne, Parkville 3052, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Drummer, Heidi E" sort="Drummer, Heidi E" uniqKey="Drummer H" first="Heidi E." last="Drummer">Heidi E. 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Brown</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, University of Melbourne, Parkville 3052, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Virology</title><title level="j" type="abbrev">YVIRO</title><idno type="ISSN">0042-6822</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">198</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="613">613</biblScope><biblScope unit="page" to="623">623</biblScope></imprint><idno type="ISSN">0042-6822</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0042-6822</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Helper T-cell clones were isolated from BALB/c mice that had been inoculated with purified light chain (HA2) from H3 subtype influenza virus hemagglutinin (HA). The clones were divided into two distinct groups based on their ability to proliferate in response to bromelain-derived HA (BHA) and the light chain derived from it (BHA2), both of which lack the C-terminal 46 amino acid residues of the HA2 chain. The first group contained two I-Ad restricted clones that proliferated in response to BHA and BHA2 and were found to recognize the determinant 96 AELLVALEN104. The remaining seven clones were I-Ed restricted, required intact HA2 for proliferation, and responded to synthetic peptides containing the sequence 170 RFQIKGVEL178 which spans the bromelain cleavage site. Although all T-cell clones proliferated in response to a wide range of different H3 virus strains, they showed no cross-reactivity with viruses of the H1 or H2 subtype. The T-cell clones from each group were able to provide help to virus-primed B cells allowing them to produce anti-HA antibody in vitro.</div></front></TEI><affiliations><list><country><li>Australie</li></country><region><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Jackson, David C" sort="Jackson, David C" uniqKey="Jackson D" first="David C." last="Jackson">David C. Jackson</name></region><name sortKey="Brown, Lorena E" sort="Brown, Lorena E" uniqKey="Brown L" first="Lorena E." last="Brown">Lorena E. Brown</name><name sortKey="Drummer, Heidi E" sort="Drummer, Heidi E" uniqKey="Drummer H" first="Heidi E." last="Drummer">Heidi E. Drummer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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